Hydroxychloroquine EP Impurity B Hydrogen sulfate CAS 103152-84-7(free base)
| CAS No. | 103152-84-7(free base) |
| Molecular Formula | C18H26ClN3O4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Hydroxychloroquine EP Impurity B Hydrogen sulfate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Hydroxychloroquine EP Impurity B Hydrogen sulfate (CAS 103152-84-7(free base), C18H26ClN3O4SH2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Hydroxychloroquine EP Impurity B Hydrogen sulfate (C18H26ClN3O4SH2O4S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Hydroxychloroquine EP Impurity B Hydrogen sulfate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H26ClN3O4S H2O4S |
| Molecular Weight | 514.00 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 75 (CAS 100713-49-3)
- Hydroxychloroquine EP Impurity B (CAS 103152-84-7)
- Hydroxychloroquine EP Impurity E (CAS 10500-64-8)
- Hydroxychloroquine Impurity 32 (CAS 106007-99-2)
- Hydroxychloroquine Impurity 30 (CAS 1077-74-3)
- Hydroxychloroquine Impurity 53 (CAS 109-83-1)
- Hydroxychloroquine D5 (CAS 118-42-3(Unlabelled))
- Hydroxychloroquine EP Impurity G Hydrochloride (CAS 1198-39-6)
Recommended Standards
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- Zidovudine EP Impurity C (CAS 65-71-4)
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- 2-Ethyl-4-hydroxybenzenesulfonamide (CAS 1243471-59-1)
- ML-213 (CAS 489402-47-3)
- 1-Benzyl-3,5-dimethyl-1H-pyrazole (CAS 1134-81-2)
- Ethyl (5-hydroxypent-1-en-3-yl)carbamate (CAS 175431-34-2)
- 1β,3α,7β-Trihydroxy-5β-cholanic Acid (CAS 108179-87-9)
- 110207-62-0 Acetyl-Cholecystokinin Octapeptide (2-8) (sulfated) MFCD00133565 (CAS 110207-62-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com